Saturday, April 20, 2013

Entropy

"Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

Anthony Samsel 1 and Stephanie Seneff 2,*

1 Independent Scientist and Consultant, Deerfield, NH 03037, USA;

E-Mail: anthonysamsel@acoustictracks.net

2 Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA

* Author to whom correspondence should be addressed; E-Mail: Seneff@csail.mit.edu;

Tel.: +1-617-253-0451; Fax: +1-617-258-8642.

Received: 15 January 2013; in revised form: 10 April 2013 / Accepted: 10 April 2013 /Published: 18 April 2013

Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide

used worldwide. The industry asserts it is minimally toxic to humans, but here we argue

otherwise. Residues are found in the main foods of the Western diet, comprised primarily

of sugar, corn, soy and wheat. Glyphosate's inhibition of cytochrome P450 (CYP) enzymes

is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in

biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging

effects of other food borne chemical residues and environmental toxins. Negative impact

on the body is insidious and manifests slowly over time as inflammation damages cellular

systems throughout the body. Here, we show how interference with CYP enzymes acts

synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria,

as well as impairment in serum sulfate transport. Consequences are most of the diseases

and conditions associated with a Western diet, which include gastrointestinal disorders,

obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s

disease. We explain the documented effects of glyphosate and its ability to induce disease,

and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the

disruption of homeostasis by environmental toxins.

Keywords: glyphosate; cytochrome P450; eNOS; obesity; cardiovascular disease; cancer; colitis; shikimate pathway; gut microbiome; tryptophan; tyrosine; phenylalanine; methionine; serotonin; Alzheimer’s disease; Parkinson’s disease; autism; depression."

What is entropy?

This abstract explains a lot of the questions my doctors and their friends have had for me this past year or two.  I am passing this on for their review.  I want to get to the bottom of this together.   This is some of my non GMO corn in 2010 which yielded well but showed some of the signs that lead to this entropy later on.  There were some black lesions leaking plant milk, dwarf mature plants and kernals that looked funny, though I raised it as pure as I could.  It followed RR soybeans that had been raised on this farm for several years.

If you want a copy of the document, email me.  I may post more parts of it for discussion.

 What do you think?   Ed

8 comments:

  1. Link to the full paper here: http://www.mdpi.com/1099-4300/15/4/1416/pdf
    It's rather long (50 pages) and technical, but I strongly recommend reading it to forge your own opinion. I would only discard any result linked to the Séralini 2-year long study, which has been criticized, not for its results, but for the small number of rats used in each sample (only 10 of each sex).

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  2. It should be noted that Anthony Samsel is an environmentalist and this paper has bias. This is a research paper with an enormous bibliography. A research paper is only as credible an its sources. As chimel noted some of the sources were authored by Seralini who has been accused of manipulating data to support his positions (anti-gmo). So the content of this work has questionable credibility.

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  3. I understand but it explains many of the things I have seen happen since GMO's were introduced. I keep looking for more sources and they are out there. There has been a huge effort to keep the science viable.

    Ed

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  4. As far as I know, Séralini has not been accused of manipulating data, but of using the same number of rats for each sample in its 2 year study as Monsanto used in their 90 day study for the exact same GM cultivar. What is perfectly acceptable for Monsanto suddenly becomes unacceptable for Séralini, talk about double standards. I agree though with the critics, 10 rats of each sex per sample is not enough. By inference, this means that all the Monsanto studies also using 10 rats per sample are just irrelevant, not even mentioning the limited duration of 90 days.

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  5. To me not releasing data for peer review and manipulating data are one and the same.

    http://www.geneticliteracyproject.org/2012/11/19/anti-gm-corn-study-reconsidered-seralini-finally-responds-to-torrent-of-criticism/

    Bad science beyond a shadow of a doubt.

    ReplyDelete
  6. Situated at the fringe of short distance to city, Sant
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  7. A "textbook example" of "exogenous semiotic entropy?". Hardly, since the term was invented in this particular paper. Show me a textbook where this exists...

    ReplyDelete

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