Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
Anthony Samsel 1 and Stephanie Seneff 2,*
1 Independent Scientist and Consultant, Deerfield, NH 03037, USA;
2 Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA
* Author to whom correspondence should be addressed; E-Mail: Seneff@csail.mit.edu;
Tel.: +1-617-253-0451; Fax: +1-617-258-8642.
Received: 15 January 2013; in revised form: 10 April 2013 / Accepted: 10 April 2013 /Published: 18 April 2013
Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide
used worldwide. The industry asserts it is minimally toxic to humans, but here we argue
otherwise. Residues are found in the main foods of the Western diet, comprised primarily
of sugar, corn, soy and wheat. Glyphosate's inhibition of cytochrome P450 (CYP) enzymes
is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in
biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging
effects of other food borne chemical residues and environmental toxins. Negative impact
on the body is insidious and manifests slowly over time as inflammation damages cellular
systems throughout the body. Here, we show how interference with CYP enzymes acts
synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria,
as well as impairment in serum sulfate transport. Consequences are most of the diseases
and conditions associated with a Western diet, which include gastrointestinal disorders,
obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s
disease. We explain the documented effects of glyphosate and its ability to induce disease,
and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the
disruption of homeostasis by environmental toxins.
Keywords: glyphosate; cytochrome P450; eNOS; obesity; cardiovascular disease; cancer; colitis; shikimate pathway; gut microbiome; tryptophan; tyrosine; phenylalanine; methionine; serotonin; Alzheimer’s disease; Parkinson’s disease; autism; depression."
What is entropy?
This abstract explains a lot of the questions my doctors and their friends have had for me this past year or two. I am passing this on for their review. I want to get to the bottom of this together. This is some of my non GMO corn in 2010 which yielded well but showed some of the signs that lead to this entropy later on. There were some black lesions leaking plant milk, dwarf mature plants and kernals that looked funny, though I raised it as pure as I could. It followed RR soybeans that had been raised on this farm for several years.
If you want a copy of the document, email me. I may post more parts of it for discussion.
What do you think? Ed